Sapienza University of Rome Sapienza University of Rome Rome, Lazio, Italy
Background: Perccutaneous thermal segmentectomy first long term clinical data worlwide
Purpose/Objective: To report the mid-term oncological results of a multicenter retrospective experience on percutaneous thermal segmentectomy (single-step combination of balloon-occluded MWA -bMWA- followed by balloon-occluded TACE -bTACE-) in patients with liver malignancies > 3cm.
Materials & Methods: Sixty-four patients with liver malignancies (hepatocellular carcinoma, HCC=50; intra-hepatic cholangiocarcinoma, iCC=3) and metastasis (n= 11) were treated. Maximum mean diameter of lesions was 4.4cm (± 1cm, range: 3.1-6.5 cm). Treatments were performed using a single-step approach: bMWA was performed after balloon-microcatheter inflation, followed by bTACE (with epirubicin or irinotecan). Oncological results at 1 month and a 3 months interval, until 15-18 months, were evaluated using m-RECIST (HCC) and RECISTv1.1 (metastasis/iCC)
Results: Complete response rate and partial response rates were respectively 79.7% (51/64) and 20.3% (13/64) at 1 month, 81.5% (44/54) and 16.7% (9/54) at 3-6 months, 74.4% (29/39) and 22.3% (8/39) at 6-9 months, 70.8% (17/24) and 25% (6/24) at 9-12 months, 73.3% (11/15) and 26.7% (4/15) at 15-18 months. Local progression-free rates were 100% at 1 month and 12-15 months follow-up, 98.2% (53/54) at 3-6 months, 94.9% (37/39) at 6-9 months, 95.8% (23/24) at 9-12 months.
Conclusion: b-MWA followed by b-TACE in a single-step permitted to safely achieve promising oncological results in patients with > 3 cm tumors.
